The beer component hordenine inhibits alcohol addiction‐associated behaviours in mice

Alcohol consumption is a widespread behaviour that may eventually result in the development of alcohol use disorder (AUD). Alcohol, however, rarely consumed pure form but fruit- or corn-derived preparations, like beer. These preparations add other compounds to consumption, which critically modify intake and AUD risk. We investigated effects hordenine, barley-derived beer compound on use-related behaviours. found dopamine D2 receptor agonist hordenine (50 mg/kg) limited ongoing prophylactically diminished relapse drinking after withdrawal mice. Although not having reinforcing its own, blocked establishment alcohol-induced conditioned place preference (CPP). However, it independently enhanced CPP retrieval. Hordenine had dose-dependent inhibitory effect locomotor activity. Chronic exposure monoamine tissue levels many brain regions. Further characterization revealed monoaminergic binding sites strong serotonin transporters, D3, adrenergic α1A α2A activation no GABAA glycinergic signalling. findings suggest natural ingredients beer, work as an use-regulating factor by their modulation signalling brain.